Version 5.4
Mus musculus Protein: Shoc2
Summary
InnateDB Protein IDBP-622293.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shoc2
Protein Name soc-2 (suppressor of clear) homolog (C. elegans)
Synonyms AU017287; mKIAA0862; Sur8;
Species Mus musculus
Ensembl Protein ENSMUSP00000127932
InnateDB Gene IDBG-176996 (Shoc2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0046579 positive regulation of Ras protein signal transduction
Cellular Component
GO:0000164 protein phosphatase type 1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1927197
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88520
PhosphoSite PhosphoSite-O88520
TrEMBL
UniProt Splice Variant
Entrez Gene 56392
UniGene Mm.418422
RefSeq NP_001161977
MGI ID
MGI Symbol Shoc2
OMIM
CCDS CCDS29904
HPRD
IMGT
EMBL AF068921 AK077798 AK146447 BC013722 BC049775 BC083060 DQ479926
GenPept AAC40175 AAH13722 AAH49775 AAH83060 ABF48505 BAC37016 BAE27179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca