Version 5.4
Mus musculus Gene: Shoc2
Summary
InnateDB Gene IDBG-176996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shoc2
Gene Name soc-2 (suppressor of clear) homolog (C. elegans)
Synonyms AU017287; mKIAA0862; Sur8
Species Mus musculus
Ensembl Gene ENSMUSG00000024976
Encoded Proteins
IDBP-176998
soc-2 (suppressor of clear) homolog (C. elegans)
IDBP-622293
soc-2 (suppressor of clear) homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108061:
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:53944306-54033268
Strand Forward strand
Band D2
Transcripts
ENSMUST00000025932 ENSMUSP00000025932
ENSMUST00000169861 ENSMUSP00000127932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0046579 positive regulation of Ras protein signal transduction
Cellular Component
GO:0000164 protein phosphatase type 1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108061
View Gene Order
ENSBTAG00000007709
Not yet available
Cross-References
SwissProt O88520
TrEMBL
UniProt Splice Variant
Entrez Gene 56392
UniGene Mm.228669 Mm.418422
RefSeq NM_019658 XM_006527227 XM_006527228 NM_001168505
OMIM
CCDS CCDS29904
HPRD
IMGT
MGI ID MGI:1927197
MGI Symbol Shoc2
EMBL AF068921 AK077798 AK146447 BC013722 BC049775 BC083060 DQ479926
GenPept AAC40175 AAH13722 AAH49775 AAH83060 ABF48505 BAC37016 BAE27179
RNA Seq Atlas 56392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca