Mus musculus Protein: Gabbr1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-622320.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Gabbr1 | ||||||||||||||||||||||
Protein Name | gamma-aminobutyric acid (GABA) B receptor, 1 | ||||||||||||||||||||||
Synonyms | bM573K1.1; GABAB1; GABAbR1; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000134268 | ||||||||||||||||||||||
InnateDB Gene | IDBG-182141 (Gabbr1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. {ECO:0000269PubMed:10773016}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in neuronal tissue including cortex, cerebellum and spinal cord. Not detected in non-neuronal tissues including heart, liver, spleen and kidney. {ECO:0000269PubMed:11306808}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1860139 | ||||||||||||||||||||||
InterPro |
IPR001828
Extracellular ligand-binding receptor IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B IPR002456 GPCR, family 3, gamma-aminobutyric acid receptor, type B1 IPR017978 GPCR, family 3, C-terminal IPR028082 Periplasmic binding protein-like I |
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PFAM |
PF01094
PF00003 |
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PRINTS |
PR01177
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PIRSF | |||||||||||||||||||||||
SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9WV18 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9WV18 | ||||||||||||||||||||||
TrEMBL | Q8CAF8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 54393 | ||||||||||||||||||||||
UniGene | Mm.412768 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Gabbr1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF008649 AF114168 AF120255 AK038844 AL078630 BC054735 BC056990 | ||||||||||||||||||||||
GenPept | AAD22194 AAG29338 AAG29341 AAH54735 AAH56990 BAC30149 | ||||||||||||||||||||||