Mus musculus Protein: Serpina1b
Summary
InnateDB Protein IDBP-622331.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpina1b
Protein Name serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms D12Ucla2; Dom2; PI2; Spi1-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000127266
InnateDB Gene IDBG-167429 (Serpina1b)
Protein Structure
UniProt Annotation
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. {ECO:0000269PubMed:11961105, ECO:0000269PubMed:8619829}.
Subcellular Localization Secreted {ECO:0000269PubMed:11961105, ECO:0000269PubMed:8619829}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006487 protein N-linked glycosylation
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0034097 response to cytokine
GO:0043434 response to peptide hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:891970
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22599
PhosphoSite PhosphoSite-P22599
TrEMBL
UniProt Splice Variant
Entrez Gene 20701
UniGene Mm.439695
RefSeq
MGI ID
MGI Symbol Serpina1b
OMIM
CCDS CCDS26138
HPRD
IMGT
EMBL AF481949 BC022109 BC025445 BC049255 M25529 M75716
GenPept AAA37132 AAC28865 AAH22109 AAH25445 AAH49255 AAM47489