Version 5.4
Mus musculus Protein: Fyco1
Summary
InnateDB Protein IDBP-622372.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fyco1
Protein Name FYVE and coiled-coil domain containing 1
Synonyms 2810409M01Rik; Mem2; RUFY3; ZFYVE7;
Species Mus musculus
Ensembl Protein ENSMUSP00000133222
InnateDB Gene IDBG-206471 (Fyco1)
Protein Structure
UniProt Annotation
Function May mediate microtubule plus end-directed vesicle transport. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, autophagosome {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart and testis. Expressed in the eye lens. {ECO:0000269PubMed:12461651, ECO:0000269PubMed:21636066}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0072383 plus-end-directed vesicle transport along microtubule
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:107277
InterPro IPR000306 FYVE zinc finger
IPR004012 RUN
IPR009038 GOLD
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PF02759
PF01105
PF13897
PRINTS
PIRSF
SMART SM00064
SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDC1
PhosphoSite PhosphoSite-Q8VDC1
TrEMBL Z4YNC0
UniProt Splice Variant
Entrez Gene 17281
UniGene Mm.401205
RefSeq NP_001103723
MGI ID
MGI Symbol Fyco1
OMIM
CCDS CCDS40819
HPRD
IMGT
EMBL AC165425 AC242669 AC242682 AJ428065 AK044587 AK081259 BC053712
GenPept AAH53712 BAC38178 BAE43322 CAD20987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca