InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xrcc6

Summary

InnateDB Protein

IDBP-622424.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrcc6

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms

70kDa; G22p1; Ku70;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126245

InnateDB Gene

IDBG-165874 (Xrcc6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 210 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	210 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006974	cellular response to DNA damage stimulus
GO:0007420	brain development
GO:0010212	response to ionizing radiation
GO:0033151	V(D)J recombination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050769	positive regulation of neurogenesis
GO:0071475	cellular hyperosmotic salinity response
GO:0071481	cellular response to X-ray

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex

Protein Structure and Domains

PDB ID

MGI:95606

InterPro

IPR002035 von Willebrand factor, type A
IPR005161 Ku70/Ku80, N-terminal alpha/beta
IPR006165 Ku70

PFAM

PF00092
PF03731

PRINTS

PIRSF

PIRSF003033

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q4A4

UniProt Splice Variant

Entrez Gene

14375

UniGene

Mm.288809

RefSeq

MGI ID

MGI Symbol

Xrcc6

OMIM

CCDS

HPRD

IMGT

EMBL

AC102176

GenPept