InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnmt3a

Summary

InnateDB Protein

IDBP-622434.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt3a

Protein Name

DNA methyltransferase 3A

Synonyms

MmuIIIA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133938

InnateDB Gene

IDBG-127800 (Dnmt3a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0045322	unmethylated CpG binding
GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0007283	spermatogenesis
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0043045	DNA methylation involved in embryo development
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046499	S-adenosylmethioninamine metabolic process
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

MGI:1261827

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3UZU0

UniProt Splice Variant

Entrez Gene

13435

UniGene

Mm.5001

RefSeq

MGI ID

MGI Symbol

Dnmt3a

OMIM

CCDS

HPRD

IMGT

EMBL

AC159324 CR974568

GenPept