InnateDB Protein
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IDBP-622664.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Papola
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Protein Name
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poly (A) polymerase alpha
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Synonyms
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Pap; PapIII; Plap;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000128908
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InnateDB Gene
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IDBG-169752 (Papola)
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Protein Structure
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Function |
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, thymus, lung, kidney, bladder, testis and spleen. {ECO:0000269PubMed:18281463}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109301
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InterPro |
IPR002934
Nucleotidyl transferase domain
IPR007012
Poly(A) polymerase, central domain
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PFAM |
PF01909
PF04928
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61183
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PhosphoSite |
PhosphoSite-Q61183
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TrEMBL |
E9QAN5
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UniProt Splice Variant |
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Entrez Gene |
18789
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UniGene |
Mm.486949
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RefSeq |
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MGI ID |
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MGI Symbol |
Papola
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB086650
AC144543
AC158526
U52197
U58134
U58135
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GenPept |
AAC52586
AAC52608
AAC52609
BAC00996
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