InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GFPT2

Summary

InnateDB Protein

IDBP-62275.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFPT2

Protein Name

glutamine-fructose-6-phosphate transaminase 2

Synonyms

GFAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000253778

InnateDB Gene

IDBG-62273 (GFPT2)

Protein Structure

UniProt Annotation

Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest levels of expression in heart, placenta, and spinal cord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process
GO:0006112	energy reserve metabolic process
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008152	metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000583 Class II glutamine amidotransferase domain
IPR001347 Sugar isomerase (SIS)
IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF00310
PF13537
PF01380
PF13580

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94808

PhosphoSite