InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgfb1i1

Summary

InnateDB Protein

IDBP-622765.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgfb1i1

Protein Name

transforming growth factor beta 1 induced transcript 1

Synonyms

ARA55; hic-5; Hic5; TSC-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131705

InnateDB Gene

IDBG-210610 (Tgfb1i1)

Protein Structure

UniProt Annotation

Function

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269PubMed:10649439, ECO:0000269PubMed:10848625, ECO:0000269PubMed:11463817, ECO:0000269PubMed:11546764, ECO:0000269PubMed:11937715, ECO:0000269PubMed:12153727, ECO:0000269PubMed:14755691, ECO:0000269PubMed:15687259, ECO:0000269PubMed:15713747, ECO:0000269PubMed:16183059, ECO:0000269PubMed:16291758, ECO:0000269PubMed:16737959, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:17299801, ECO:0000269PubMed:7929412, ECO:0000269PubMed:9722648}.

Subcellular Localization

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level). {ECO:0000269PubMed:12177201, ECO:0000269PubMed:15713747, ECO:0000269PubMed:16219310, ECO:0000269PubMed:16219691, ECO:0000269PubMed:17233630, ECO:0000269PubMed:7929412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0048495	Roundabout binding
GO:0050681	androgen receptor binding
GO:0070411	I-SMAD binding

Biological Process

GO:0009408	response to heat
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0016331	morphogenesis of embryonic epithelium
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0030855	epithelial cell differentiation
GO:0045165	cell fate commitment
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated