Version 5.4
Mus musculus Gene: Tgfb1i1
Summary
InnateDB Gene IDBG-210610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgfb1i1
Gene Name transforming growth factor beta 1 induced transcript 1
Synonyms ARA55; hic-5; Hic5; TSC-5
Species Mus musculus
Ensembl Gene ENSMUSG00000030782
Encoded Proteins
IDBP-210612
transforming growth factor beta 1 induced transcript 1
IDBP-622752
transforming growth factor beta 1 induced transcript 1
IDBP-622765
transforming growth factor beta 1 induced transcript 1
IDBP-622769
transforming growth factor beta 1 induced transcript 1
IDBP-622770
transforming growth factor beta 1 induced transcript 1
IDBP-622776
transforming growth factor beta 1 induced transcript 1
IDBP-622778
transforming growth factor beta 1 induced transcript 1
IDBP-622780
transforming growth factor beta 1 induced transcript 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140682:
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128246812-128253712
Strand Forward strand
Band F3
Transcripts
ENSMUST00000070656 ENSMUSP00000068529
ENSMUST00000164710 ENSMUSP00000130964
ENSMUST00000169919 ENSMUSP00000131705
ENSMUST00000167965 ENSMUSP00000132100
ENSMUST00000163609 ENSMUSP00000133134
ENSMUST00000168825 ENSMUSP00000132685
ENSMUST00000163553
ENSMUST00000166755
ENSMUST00000171888
ENSMUST00000165667 ENSMUSP00000127695
ENSMUST00000170115 ENSMUSP00000129958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0048495 Roundabout binding
GO:0050681 androgen receptor binding
GO:0070411 I-SMAD binding
Biological Process
GO:0009408 response to heat
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0030855 epithelial cell differentiation
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016363 nuclear matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140682
View Gene Order
ENSBTAG00000002391
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt Q62219
TrEMBL
UniProt Splice Variant
Entrez Gene 21804
UniGene Mm.3248
RefSeq NM_001289550 NM_001289551 NM_001289553 NM_009365 XM_006507566 XM_006507567 XM_006507568 XM_006507569
OMIM
CCDS CCDS21893
HPRD
IMGT
MGI ID MGI:102784
MGI Symbol Tgfb1i1
EMBL AF083064 AK156423 AK158409 BC002049 BC056362 DQ143891 DQ143892 DQ143893 DQ143894 DQ143895 DQ143896 DQ143897 DQ143898 DQ143899 DQ143900 L22482
GenPept AAA62226 AAD51090 AAH02049 AAH56362 AAZ82195 AAZ82196 AAZ82197 AAZ82198 AAZ82199 AAZ82200 AAZ82201 AAZ82202 AAZ82203 AAZ82204 BAE33707 BAE34493
RNA Seq Atlas 21804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca