InnateDB Protein
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IDBP-622770.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tgfb1i1
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Protein Name
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transforming growth factor beta 1 induced transcript 1
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Synonyms
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ARA55; hic-5; Hic5; TSC-5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000133134
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InnateDB Gene
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IDBG-210610 (Tgfb1i1)
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Protein Structure
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Function |
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269PubMed:10649439, ECO:0000269PubMed:10848625, ECO:0000269PubMed:11463817, ECO:0000269PubMed:11546764, ECO:0000269PubMed:11937715, ECO:0000269PubMed:12153727, ECO:0000269PubMed:14755691, ECO:0000269PubMed:15687259, ECO:0000269PubMed:15713747, ECO:0000269PubMed:16183059, ECO:0000269PubMed:16291758, ECO:0000269PubMed:16737959, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:17299801, ECO:0000269PubMed:7929412, ECO:0000269PubMed:9722648}.
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Subcellular Localization |
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level). {ECO:0000269PubMed:12177201, ECO:0000269PubMed:15713747, ECO:0000269PubMed:16219310, ECO:0000269PubMed:16219691, ECO:0000269PubMed:17233630, ECO:0000269PubMed:7929412}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
GO:0009408
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response to heat
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GO:0010718
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positive regulation of epithelial to mesenchymal transition
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GO:0016055
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Wnt signaling pathway
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GO:0016331
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morphogenesis of embryonic epithelium
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GO:0030511
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positive regulation of transforming growth factor beta receptor signaling pathway
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GO:0030512
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negative regulation of transforming growth factor beta receptor signaling pathway
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GO:0030579
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ubiquitin-dependent SMAD protein catabolic process
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GO:0030855
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epithelial cell differentiation
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GO:0045165
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cell fate commitment
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GO:0045599
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negative regulation of fat cell differentiation
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:102784
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InterPro |
IPR001781
Zinc finger, LIM-type
IPR017305
Transforming growth factor beta-1-induced transcript 1 protein/Leupaxin
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PFAM |
PF00412
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PRINTS |
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PIRSF |
PIRSF037881
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q62219
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PhosphoSite |
PhosphoSite-Q62219
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21804
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UniGene |
Mm.3248
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RefSeq |
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MGI ID |
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MGI Symbol |
Tgfb1i1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF083064
AK156423
AK158409
BC002049
BC056362
DQ143891
DQ143892
DQ143893
DQ143894
DQ143895
DQ143896
DQ143897
DQ143898
DQ143899
DQ143900
L22482
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GenPept |
AAA62226
AAD51090
AAH02049
AAH56362
AAZ82195
AAZ82196
AAZ82197
AAZ82198
AAZ82199
AAZ82200
AAZ82201
AAZ82202
AAZ82203
AAZ82204
BAE33707
BAE34493
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