InnateDB Protein
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IDBP-622782.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aldh7a1
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Protein Name
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aldehyde dehydrogenase family 7, member A1
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Synonyms
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Atq1; D18Wsu181e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000133372
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InnateDB Gene
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IDBG-147695 (Aldh7a1)
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Protein Structure
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Function |
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:20207735}. Nucleus {ECO:0000269PubMed:20207735}. Cytoplasm, cytosol {ECO:0000269PubMed:20207735}.
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Disease Associations |
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Tissue Specificity |
Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level). {ECO:0000269PubMed:20207735}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:108186
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InterPro |
IPR015590
Aldehyde dehydrogenase domain
IPR016161
Aldehyde/histidinol dehydrogenase
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PFAM |
PF00171
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DBF1
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PhosphoSite |
PhosphoSite-Q9DBF1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
110695
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UniGene |
Mm.30250
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RefSeq |
NP_001120810
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MGI ID |
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MGI Symbol |
Aldh7a1
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OMIM |
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CCDS |
CCDS50291
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HPRD |
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IMGT |
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EMBL |
AK004991
AK145873
AK160117
AK169195
BC012407
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GenPept |
AAH12407
BAB23726
BAE26715
BAE35641
BAE40971
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