Version 5.4
Mus musculus Protein: Unc13d
Summary
InnateDB Protein IDBP-622788.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc13d
Protein Name unc-13 homolog D (C. elegans)
Synonyms 2610108D09Rik; Jinx; mFLJ00067; Munc13-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000133679
InnateDB Gene IDBG-214399 (Unc13d)
Protein Structure
UniProt Annotation
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells. {ECO:0000250, ECO:0000269PubMed:18354201}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Late endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Lysosome {ECO:0000269PubMed:18354201}. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity Mast cells. {ECO:0000269PubMed:18354201}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002432 granuloma formation
GO:0002467 germinal center formation
GO:0006909 phagocytosis
GO:0043304 regulation of mast cell degranulation
GO:0043320 natural killer cell degranulation
GO:0045921 positive regulation of exocytosis
GO:0051607 defense response to virus
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0055037 recycling endosome
GO:0070382 exocytic vesicle
Protein Structure and Domains
PDB ID MGI:1917700
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B2RUP2
PhosphoSite PhosphoSite-B2RUP2
TrEMBL A2A858
UniProt Splice Variant
Entrez Gene 70450
UniGene Mm.259460
RefSeq
MGI ID
MGI Symbol Unc13d
OMIM
CCDS
HPRD
IMGT
EMBL AK220199 AL607108 BC141289 EF127645 EF127646
GenPept AAI41290 ABO15439 ABO15440 BAD90124 CAM24043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca