InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dyrk1b

Summary

InnateDB Protein

IDBP-622871.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyrk1b

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b

Synonyms

Mirk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133364

InnateDB Gene

IDBG-162371 (Dyrk1b)

Protein Structure

UniProt Annotation

Function

Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. {ECO:0000269PubMed:12633499}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level). {ECO:0000269PubMed:12633499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007520	myoblast fusion
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1330302

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt