InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slamf6

Summary

InnateDB Protein

IDBP-622892.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slamf6

Protein Name

SLAM family member 6

Synonyms

KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130610

InnateDB Gene

IDBG-204886 (Slamf6)

Protein Structure

UniProt Annotation

Function

May rather modulate immune responses. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. {ECO:0000269PubMed:18031695}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed on hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1353620

InterPro

IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ET39

PhosphoSite

PhosphoSite-Q9ET39

TrEMBL

Q18PG5

UniProt Splice Variant

Entrez Gene

30925

UniGene

RefSeq

NP_109635

MGI ID

MGI Symbol

Slamf6

OMIM

CCDS

CCDS15504

HPRD

IMGT

EMBL

AB196836 AF248635 AF248636 BC030031 CH466520

GenPept

AAG01737 AAG01738 AAH30031 BAE96339 EDL39050