InnateDB Protein
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IDBP-622902.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pum2
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Protein Name
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pumilio 2 (Drosophila)
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Synonyms
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5730503J23Rik; mKIAA0235; Pumm2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000131074
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InnateDB Gene
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IDBG-128407 (Pum2)
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Protein Structure
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Function |
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305PubMed:19861488}. Cytoplasmic granule {ECO:0000269PubMed:19861488}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells (By similarity). Colocalizes with NANOS3 in the stress granules. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in embryonic stem cells, heart, kidney, lung, skin, intestine, spleen and thymus. Expressed at intermediate level in brain and liver. Weakly or not expressed in muscles and stomach. Expressed at various stages of myeloid and lymphoid cell development. In the testis expressed in the spermatogoni, spermatocytes, spermatids and Sertoli cells. {ECO:0000269PubMed:11780640, ECO:0000269PubMed:12667987, ECO:0000269PubMed:18089289}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1931751
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InterPro |
IPR001313
Pumilio RNA-binding repeat
IPR016024
Armadillo-type fold
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PFAM |
PF00806
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PRINTS |
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PIRSF |
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SMART |
SM00025
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TIGRFAMs |
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Modification |
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SwissProt |
Q80U58
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PhosphoSite |
PhosphoSite-Q80U58
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TrEMBL |
E9Q765
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UniProt Splice Variant |
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Entrez Gene |
80913
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UniGene |
Mm.419047
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RefSeq |
NP_001153691
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MGI ID |
3GVT
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MGI Symbol |
Pum2
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OMIM |
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CCDS |
CCDS25802
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HPRD |
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IMGT |
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EMBL |
AC110382
AC134245
AF315590
AK122225
AY027917
BC013765
BC041773
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GenPept |
AAG31805
AAH13765
AAH41773
AAK21966
BAC65507
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