InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp39a1

Summary

InnateDB Protein

IDBP-623102.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp39a1

Protein Name

cytochrome P450, family 39, subfamily a, polypeptide 1

Synonyms

mCYP39A1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130073

InnateDB Gene

IDBG-184577 (Cyp39a1)

Protein Structure

UniProt Annotation

Function

Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Liver specific. Hepatic expression is sexually dimorphic (female > male).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008387	steroid 7-alpha-hydroxylase activity
GO:0008396	oxysterol 7-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033782	24-hydroxycholesterol 7alpha-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0007586	digestion
GO:0030573	bile acid catabolic process
GO:0055114	oxidation-reduction process