InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp39a1

Summary

InnateDB Gene

IDBG-184577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp39a1

Gene Name

cytochrome P450, family 39, subfamily a, polypeptide 1

Synonyms

mCYP39A1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023963

Encoded Proteins

IDBP-623102

cytochrome P450, family 39, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146233:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43667425-43751431

Strand

Forward strand

Band

Transcripts

ENSMUST00000170988

ENSMUSP00000130073

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008387	steroid 7-alpha-hydroxylase activity
GO:0008396	oxysterol 7-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033782	24-hydroxycholesterol 7alpha-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0007586	digestion
GO:0030573	bile acid catabolic process
GO:0055114	oxidation-reduction process