InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPM1D

Summary

InnateDB Protein

IDBP-62325.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1D

Protein Name

protein phosphatase, Mg2+/Mn2+ dependent, 1D

Synonyms

PP2C-DELTA; WIP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000306682

InnateDB Gene

IDBG-62323 (PPM1D)

Protein Structure

UniProt Annotation

Function

Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. {ECO:0000269PubMed:15870257, ECO:0000269PubMed:16311512}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0009314	response to radiation
GO:0009617	response to bacterium
GO:0035970	peptidyl-threonine dephosphorylation