Version 5.4
Homo sapiens Gene: PPM1D
Summary
InnateDB Gene IDBG-62323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1D
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1D
Synonyms PP2C-DELTA; WIP1
Species Homo sapiens
Ensembl Gene ENSG00000170836
Encoded Proteins
IDBP-62325
protein phosphatase, Mg2+/Mn2+ dependent, 1D
IDBP-244517
protein phosphatase, Mg2+/Mn2+ dependent, 1D
IDBP-761025
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:60600183-60666280
Strand Forward strand
Band q23.2
Transcripts
ENST00000305921 ENSP00000306682
ENST00000392995 ENSP00000376720
ENST00000590418 ENSP00000465168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009617 response to bacterium
GO:0035970 peptidyl-threonine dephosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020525
View Gene Order
ENSBTAG00000009427
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286073 Hs.605212
RefSeq NM_003620
HUGO
OMIM
CCDS CCDS11625
HPRD 05482
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca