InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Coro1a

Summary

InnateDB Protein

IDBP-623324.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coro1a

Protein Name

coronin, actin binding protein 1A

Synonyms

Clabp; Lmb3; p57; TACO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134123

InnateDB Gene

IDBG-209756 (Coro1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006816	calcium ion transport
GO:0007015	actin filament organization
GO:0008064	regulation of actin polymerization or depolymerization
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0030595	leukocyte chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0031589	cell-substrate adhesion
GO:0032796	uropod organization
GO:0034097	response to cytokine
GO:0042102	positive regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0048873	homeostasis of number of cells within a tissue
GO:0050870	positive regulation of T cell activation
GO:0050918	positive chemotaxis
GO:0051126	negative regulation of actin nucleation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0001772	immunological synapse
GO:0001891	phagocytic cup
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030864	cortical actin cytoskeleton
GO:0031252	cell leading edge
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

MGI:1345961

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite