InnateDB Protein
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IDBP-623326.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hormad1
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Protein Name
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HORMA domain containing 1
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Synonyms
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4921522K05Rik; Nohma;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127180
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InnateDB Gene
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IDBG-172927 (Hormad1)
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Protein Structure
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Function |
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000269PubMed:19686734, ECO:0000269PubMed:21079677, ECO:0000269PubMed:21478856}.
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Subcellular Localization |
Isoform 1: Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. Accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I. As germ cells progress into the pachytene stage, disappears from the synapsed chromosomal regions. Once the chromosomes desynapse during the diplotene stage, it again accumulates on the chromosome axis of the desynapsed homologs. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions.Isoform 2: Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in meiotic germ cells. {ECO:0000269PubMed:15567723, ECO:0000269PubMed:19686734, ECO:0000269PubMed:19851446, ECO:0000269PubMed:21079677}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915231
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InterPro |
IPR003511
DNA-binding HORMA
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PFAM |
PF02301
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D5T7
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PhosphoSite |
PhosphoSite-Q9D5T7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67981
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UniGene |
Mm.399182
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RefSeq |
NP_001276466
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MGI ID |
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MGI Symbol |
Hormad1
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OMIM |
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CCDS |
CCDS38547
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HPRD |
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IMGT |
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EMBL |
AK014945
AK016324
AK016743
AK163995
AY626343
AY634284
BC051129
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GenPept |
AAH51129
AAT45739
AAT47126
BAB29633
BAB30195
BAB30406
BAE37577
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