InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc13b

Summary

InnateDB Protein

IDBP-623327.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc13b

Protein Name

unc-13 homolog B (C. elegans)

Synonyms

Munc13-1; Munc13-2; Unc13a; Unc13h1; Unc13h2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128608

InnateDB Gene

IDBG-140233 (Unc13b)

Protein Structure

UniProt Annotation

Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. {ECO:0000250, ECO:0000269PubMed:12070347}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses (By similarity). Translocates to the Golgi in response to phorbol ester binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001566	non-kinase phorbol ester receptor activity
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016082	synaptic vesicle priming
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0060384	innervation

Cellular Component

GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030054	cell junction
GO:0031594	neuromuscular junction

Protein Structure and Domains

PDB ID

MGI:1342278

InterPro

IPR000008 C2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR010439 Calcium-dependent secretion activator
IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2

PFAM

PF00168
PF00130
PF06292
PF10540

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt