Mus musculus Gene: Unc13b | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-140233.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Unc13b | ||||||||||||||||||
Gene Name | unc-13 homolog B (C. elegans) | ||||||||||||||||||
Synonyms | Munc13-1; Munc13-2; Unc13a; Unc13h1; Unc13h2 | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Gene | ENSMUSG00000028456 | ||||||||||||||||||
Encoded Proteins |
unc-13 homolog B (C. elegans)
unc-13 homolog B (C. elegans)
unc-13 homolog B (C. elegans)
unc-13 homolog B (C. elegans)
unc-13 homolog B (C. elegans)
unc-13 homolog B (C. elegans)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198722:
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 4:43058953-43264871 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | A5 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Acetylcholine Neurotransmitter Release Cycle pathway
Neurotransmitter Release Cycle pathway
Norepinephrine Neurotransmitter Release Cycle pathway
Neuronal System pathway
Glutamate Neurotransmitter Release Cycle pathway
Transmission across Chemical Synapses pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Dopamine Neurotransmitter Release Cycle pathway
Acetylcholine Neurotransmitter Release Cycle pathway
Serotonin Neurotransmitter Release Cycle pathway
Glutamate Neurotransmitter Release Cycle pathway
Norepinephrine Neurotransmitter Release Cycle pathway
Neuronal System pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI |
Effects of Botulinum toxin
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001081413 NM_021468 XM_006537794 XM_006537795 XM_006537796 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS38738 CCDS51161 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||