InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Unc13b

Summary

InnateDB Gene

IDBG-140233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc13b

Gene Name

unc-13 homolog B (C. elegans)

Synonyms

Munc13-1; Munc13-2; Unc13a; Unc13h1; Unc13h2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028456

Encoded Proteins

IDBP-140235

unc-13 homolog B (C. elegans)

IDBP-265585

unc-13 homolog B (C. elegans)

IDBP-265587

unc-13 homolog B (C. elegans)

IDBP-623341

unc-13 homolog B (C. elegans)

IDBP-623327

unc-13 homolog B (C. elegans)

IDBP-623340

unc-13 homolog B (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198722:
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:43058953-43264871

Strand

Forward strand

Band

Transcripts

ENSMUST00000079978	ENSMUSP00000078894
ENSMUST00000107953	ENSMUSP00000103587
ENSMUST00000107952	ENSMUSP00000103586
ENSMUST00000126878
ENSMUST00000151611
ENSMUST00000132310
ENSMUST00000127597
ENSMUST00000149945
ENSMUST00000153168
ENSMUST00000145899	ENSMUSP00000128638
ENSMUST00000143653
ENSMUST00000171234
ENSMUST00000163653	ENSMUSP00000128608
ENSMUST00000164434
ENSMUST00000168032	ENSMUSP00000132622

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001566	non-kinase phorbol ester receptor activity
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016082	synaptic vesicle priming
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0060384	innervation