Version 5.4
Mus musculus Protein: Spock1
Summary
InnateDB Protein IDBP-623344.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spock1
Protein Name sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
Synonyms Spock; testican; Ticn1;
Species Mus musculus
Ensembl Protein ENSMUSP00000128840
InnateDB Gene IDBG-157690 (Spock1)
Protein Structure
UniProt Annotation
Function May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Predominantly expressed in the postsynaptic area of pyramidal neurons.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0007165 signal transduction
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010951 negative regulation of endopeptidase activity
GO:0010977 negative regulation of neuron projection development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:105371
InterPro IPR000716 Thyroglobulin type-1
IPR002350 Kazal domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00086
PF00050
PF07648
PF10591
PRINTS
PIRSF
SMART SM00211
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8BKQ3
UniProt Splice Variant
Entrez Gene 20745
UniGene Mm.379020
RefSeq
MGI ID
MGI Symbol Spock1
OMIM
CCDS CCDS49279
HPRD
IMGT
EMBL AC142258 AC154210 AC154748 AK051191 CT010428
GenPept BAC34553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca