InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsp90ab1

Summary

InnateDB Protein

IDBP-623377.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsp90ab1

Protein Name

heat shock protein 90 alpha (cytosolic), class B member 1

Synonyms

90kDa; AL022974; C81438; Hsp84; Hsp84-1; Hsp90; Hspcb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131601

InnateDB Gene

IDBG-185482 (Hsp90ab1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 528 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	71 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	528 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002134	UTP binding
GO:0002135	CTP binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0017098	sulfonylurea receptor binding
GO:0019901	protein kinase binding
GO:0032564	dATP binding
GO:0044325	ion channel binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001890	placenta development
GO:0006457	protein folding
GO:0006950	response to stress
GO:0009651	response to salt stress
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045793	positive regulation of cell size
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0071353	cellular response to interleukin-4
GO:0071407	cellular response to organic cyclic compound
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0009986	cell surface
GO:0016234	inclusion body
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

MGI:96247

InterPro

IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF02518
PF13581

PRINTS

PR00775

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9PX27

UniProt Splice Variant

Entrez Gene

15516

UniGene

Mm.413436

RefSeq

MGI ID

MGI Symbol

Hsp90ab1

OMIM

CCDS

HPRD

IMGT

EMBL

AC163677

GenPept