Version 5.4
Mus musculus Protein: Pde8b
Summary
InnateDB Protein IDBP-623450.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde8b
Protein Name phosphodiesterase 8B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128987
InnateDB Gene IDBG-173643 (Pde8b)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000156 two-component response regulator activity
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0035556 intracellular signal transduction
GO:0046676 negative regulation of insulin secretion
GO:0090032 negative regulation of steroid hormone biosynthetic process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2443999
InterPro IPR000014 PAS domain
IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR013655 PAS fold-3
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR013938 3\'5\'-cyclic nucleotide phosphodiesterase PDE8
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
PFAM PF13188
PF13426
PF00072
PF00233
PF08447
PF08448
PF00989
PF08629
PRINTS PR00387
PIRSF
SMART SM00091
SM00448
SM00471
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3UUK9
UniProt Splice Variant
Entrez Gene 218461
UniGene Mm.100167
RefSeq
MGI ID
MGI Symbol Pde8b
OMIM
CCDS
HPRD
IMGT
EMBL AC123034 AC134439 AC147108 AK138301
GenPept BAE23616

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca