InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgca

Summary

InnateDB Protein

IDBP-623452.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgca

Protein Name

sarcoglycan, alpha (dystrophin-associated glycoprotein)

Synonyms

50DAG; Asg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130617

InnateDB Gene

IDBG-209323 (Sgca)

Protein Structure

UniProt Annotation

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000269PubMed:9864373}; Single-pass type I membrane protein {ECO:0000269PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9864373}.

Disease Associations

Tissue Specificity

Striated muscle, both skeletal and cardiac. {ECO:0000269PubMed:9196068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0006936	muscle contraction
GO:0007517	muscle organ development
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016011	dystroglycan complex
GO:0016012	sarcoglycan complex
GO:0016020	membrane
GO:0042383	sarcolemma
GO:0045121	membrane raft