InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNC13B

Summary

InnateDB Protein

IDBP-62351.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC13B

Protein Name

unc-13 homolog B (C. elegans)

Synonyms

MUNC13; UNC13; Unc13h2;

Species

Homo sapiens

Ensembl Protein

ENSP00000367756

InnateDB Gene

IDBG-62347 (UNC13B)

Protein Structure

UniProt Annotation

Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney cortical epithelial cells and brain. {ECO:0000269PubMed:9607201}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0007588	excretion
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016082	synaptic vesicle priming
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0060384	innervation

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0031594	neuromuscular junction

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR010439 Calcium-dependent secretion activator
IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2

PFAM

PF00168
PF00130
PF06292
PF10540

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt