InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Odc1

Summary

InnateDB Protein

IDBP-623562.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Odc1

Protein Name

ornithine decarboxylase, structural 1

Synonyms

ODC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128661

InnateDB Gene

IDBG-129751 (Odc1)

Protein Structure

UniProt Annotation

Function

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. {ECO:0000269PubMed:18973822, ECO:0000269PubMed:24967154}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed during testis development in the outer part of the seminiferous tubules. {ECO:0000269PubMed:18973822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004586	ornithine decarboxylase activity

Biological Process

GO:0001822	kidney development
GO:0006595	polyamine metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009446	putrescine biosynthetic process
GO:0009615	response to virus
GO:0033387	putrescine biosynthetic process from ornithine

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:97402

InterPro

IPR000183 Ornithine/DAP/Arg decarboxylase
IPR002433 Ornithine decarboxylase
IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
IPR029066 PLP-binding barrel

PFAM

PF00278
PF02784

PRINTS

PR01179
PR01182

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00860