InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Odc1

Summary

InnateDB Gene

IDBG-129751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Odc1

Gene Name

ornithine decarboxylase, structural 1

Synonyms

ODC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000011179

Encoded Proteins

IDBP-623562

ornithine decarboxylase, structural 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115758:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:17544873-17551502

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000171737

ENSMUSP00000128661

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004586	ornithine decarboxylase activity

Biological Process

GO:0001822	kidney development
GO:0006595	polyamine metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009446	putrescine biosynthetic process
GO:0009615	response to virus
GO:0033387	putrescine biosynthetic process from ornithine