InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smad7

Summary

InnateDB Protein

IDBP-623796.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad7

Protein Name

MAD homolog 7 (Drosophila)

Synonyms

Madh7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129322

InnateDB Gene

IDBG-158890 (Smad7)

Protein Structure

UniProt Annotation

Function

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous in various organs, with higher levels in brain and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	41 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008013	beta-catenin binding
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0048185	activin binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0022409	positive regulation of cell-cell adhesion
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925	regulation of activin receptor signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0034333	adherens junction assembly
GO:0034616	response to laminar fluid shear stress
GO:0034629	cellular protein complex localization
GO:0035556	intracellular signal transduction
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048844	artery morphogenesis
GO:0050821	protein stabilization
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055117	regulation of cardiac muscle contraction
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412	ventricular septum morphogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005829	cytosol
GO:0005913	cell-cell adherens junction
GO:0016342	catenin complex
GO:0043234	protein complex