Version 5.4
Mus musculus Gene: Smad7
Summary
InnateDB Gene IDBG-158890.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad7
Gene Name SMAD family member 7
Synonyms Madh7
Species Mus musculus
Ensembl Gene ENSMUSG00000025880
Encoded Proteins
IDBP-158892
MAD homolog 7 (Drosophila)
IDBP-623794
MAD homolog 7 (Drosophila)
IDBP-623795
MAD homolog 7 (Drosophila)
IDBP-623796
MAD homolog 7 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12589052
[Homo sapiens] Inhibitory SMAD7, a direct target gene for transforming growth factor-beta (TGF-beta), mediates TGF-beta1-induced apoptosis in several cell types and acts as a scaffolding protein to facilitate TAK1- and MKK3-mediated activation of p38.
PMID 20171181
[Homo sapiens] SMAD7 acts as a critical mediator for effective TGF-beta1-mediated suppression of IL-1R/TLR signalling, by simultaneous binding to discrete regions of Pellino-1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101665:
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:75367529-75395935
Strand Forward strand
Band E3
Transcripts
ENSMUST00000026999 ENSMUSP00000026999
ENSMUST00000174843 ENSMUSP00000133544
ENSMUST00000174411 ENSMUSP00000133696
ENSMUST00000172718
ENSMUST00000168918 ENSMUSP00000129322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 41 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 94 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008013 beta-catenin binding
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625 ubiquitin protein ligase binding
GO:0034713 type I transforming growth factor beta receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0070411 I-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 regulation of activin receptor signaling pathway
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034333 adherens junction assembly
GO:0034616 response to laminar fluid shear stress
GO:0034629 cellular protein complex localization
GO:0035556 intracellular signal transduction
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048844 artery morphogenesis
GO:0050821 protein stabilization
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0071560 cellular response to transforming growth factor beta stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016342 catenin complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101665
View Gene Order
ENSBTAG00000012441
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_215733
Downregulation of TGF-beta receptor signaling pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_220505
Signaling by BMP pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_203903
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12034
Signaling by BMP pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
bmppathway
BMP receptor signaling
alk1pathway
ALK1 signaling events
hdac_classi_pathway
Signaling events mediated by HDAC Class I
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
tgfbrpathway
TGF-beta receptor signaling
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34407 Mm.470979
RefSeq NM_001042660 XM_006525703
OMIM
CCDS CCDS37860
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca