Version 5.4
Mus musculus Protein: Sox8
Summary
InnateDB Protein IDBP-623819.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sox8
Protein Name SRY-box containing gene 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000133403
InnateDB Gene IDBG-152312 (Sox8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0006366 transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0007422 peripheral nervous system development
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0010817 regulation of hormone levels
GO:0033690 positive regulation of osteoblast proliferation
GO:0035914 skeletal muscle cell differentiation
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048469 cell maturation
GO:0048709 oligodendrocyte differentiation
GO:0060009 Sertoli cell development
GO:0060018 astrocyte fate commitment
GO:0060041 retina development in camera-type eye
GO:0060221 retinal rod cell differentiation
GO:0060612 adipose tissue development
GO:0061138 morphogenesis of a branching epithelium
GO:0072197 ureter morphogenesis
GO:0072289 metanephric nephron tubule formation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0044798 nuclear transcription factor complex
Protein Structure and Domains
PDB ID MGI:98370
InterPro IPR009071 High mobility group box domain
IPR022151 Sox developmental protein N-terminal
PFAM PF00505
PF09011
PF12444
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UWS3
UniProt Splice Variant
Entrez Gene 20681
UniGene
RefSeq
MGI ID
MGI Symbol Sox8
OMIM
CCDS
HPRD
IMGT
EMBL AC154418
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca