InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mad2l1bp

Summary

InnateDB Protein

IDBP-623822.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mad2l1bp

Protein Name

MAD2L1 binding protein

Synonyms

0610009D16Rik; 2510031P20Rik; AU018945; AW550977; C76045; CMT2A; CMT2B; Mad2lbp; mKIAA0110;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125915

InnateDB Gene

IDBG-186056 (Mad2l1bp)

Protein Structure

UniProt Annotation

Function

May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0007096	regulation of exit from mitosis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1913841

InterPro

IPR009511 Mad1/Cdc20-bound-Mad2 binding protein

PFAM

PF06581

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DCX1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

66591

UniGene

Mm.272024

RefSeq

NP_079925

MGI ID

MGI Symbol

Mad2l1bp

OMIM

CCDS

CCDS28821

HPRD

IMGT

EMBL

AK002377 AK004224 BC005768

GenPept

AAH05768 BAB22054 BAB23226