InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chek1

Summary

InnateDB Protein

IDBP-623901.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chek1

Protein Name

checkpoint kinase 1 homolog (S. pombe)

Synonyms

C85740; Chk1; rad27;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134013

InnateDB Gene

IDBG-149248 (Chek1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0010468	regulation of gene expression
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0018107	peptidyl-threonine phosphorylation
GO:0042127	regulation of cell proliferation
GO:0045839	negative regulation of mitosis
GO:0046602	regulation of mitotic centrosome separation
GO:0071260	cellular response to mechanical stimulus
GO:0071313	cellular response to caffeine

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:1202065

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3UYB1

UniProt Splice Variant

Entrez Gene

12649

UniGene

Mm.16753

RefSeq

MGI ID

MGI Symbol

Chek1

OMIM

CCDS

HPRD

IMGT

EMBL

AC155921

GenPept