Version 5.4
Mus musculus Gene: Chek1
Summary
InnateDB Gene IDBG-149248.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chek1
Gene Name checkpoint kinase 1
Synonyms C85740; Chk1; rad27
Species Mus musculus
Ensembl Gene ENSMUSG00000032113
Encoded Proteins
IDBP-149250
checkpoint kinase 1 homolog (S. pombe)
IDBP-623897
checkpoint kinase 1 homolog (S. pombe)
IDBP-623898
checkpoint kinase 1 homolog (S. pombe)
IDBP-623900
checkpoint kinase 1 homolog (S. pombe)
IDBP-623901
checkpoint kinase 1 homolog (S. pombe)
IDBP-623907
checkpoint kinase 1 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149554:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:36708482-36727065
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000034625 ENSMUSP00000034625
ENSMUST00000172702 ENSMUSP00000134388
ENSMUST00000174105 ENSMUSP00000134398
ENSMUST00000173963 ENSMUSP00000134029
ENSMUST00000173534 ENSMUSP00000134013
ENSMUST00000174794
ENSMUST00000173796
ENSMUST00000173977
ENSMUST00000172742 ENSMUSP00000133589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035402 histone kinase activity (H3-T11 specific)
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0010468 regulation of gene expression
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0018107 peptidyl-threonine phosphorylation
GO:0031572 G2 DNA damage checkpoint
GO:0035407 histone H3-T11 phosphorylation
GO:0042127 regulation of cell proliferation
GO:0045839 negative regulation of mitosis
GO:0046602 regulation of mitotic centrosome separation
GO:0048096 chromatin-mediated maintenance of transcription
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071313 cellular response to caffeine
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000615 regulation of histone H3-K9 acetylation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000794 condensed nuclear chromosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149554
View Gene Order
ENSBTAG00000017582
Not yet available
Pathways
NETPATH
REACTOME
REACT_233330
p53-Independent G1/S DNA damage checkpoint pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_237804
p53-Independent DNA Damage Response pathway
REACT_251223
G2/M DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_232069
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_235397
G2/M Checkpoints pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_188257
Signal Transduction pathway
REACT_236786
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
KEGG
mmu04115
p53 signaling pathway pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_1614
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_2160
p53-Independent DNA Damage Response pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_1208
p53-Independent G1/S DNA damage checkpoint pathway
REACT_828
G2/M Checkpoints pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
p73pathway
p73 transcription factor network
circadianpathway
Circadian rhythm pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt O35280
TrEMBL G3UX84
UniProt Splice Variant
Entrez Gene 12649
UniGene Mm.16753
RefSeq NM_007691
OMIM
CCDS CCDS22972
HPRD
IMGT
MGI ID MGI:1202065
MGI Symbol Chek1
EMBL AC155921 AF016583 AF032875 AK011258 AK033179 AK045336 BC037613
GenPept AAB88853 AAC53334 AAH37613 BAB27500 BAC28185 BAC32315
RNA Seq Atlas 12649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca