InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLIP1

Summary

InnateDB Protein

IDBP-62400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIP1

Protein Name

CAP-GLY domain containing linker protein 1

Synonyms

CLIP; CLIP-170; CLIP170; CYLN1; RSN;

Species

Homo sapiens

Ensembl Protein

ENSP00000351665

InnateDB Gene

IDBG-62398 (CLIP1)

Protein Structure

UniProt Annotation

Function

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269PubMed:12433698, ECO:0000269PubMed:17563362, ECO:0000269PubMed:17889670}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles.

Disease Associations

Tissue Specificity

Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269PubMed:12433698, ECO:0000269PubMed:1600942}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0001578	microtubule bundle formation
GO:0006810	transport
GO:0007067	mitotic nuclear division
GO:0031116	positive regulation of microtubule polymerization

Cellular Component

GO:0000776	kinetochore
GO:0001726	ruffle
GO:0005768	endosome
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005882	intermediate filament
GO:0015630	microtubule cytoskeleton
GO:0030659	cytoplasmic vesicle membrane
GO:0035371	microtubule plus-end
GO:0044354	macropinosome