InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eno3

Summary

InnateDB Protein

IDBP-624138.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eno3

Protein Name

enolase 3, beta muscle

Synonyms

Eno-3; MSE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128714

InnateDB Gene

IDBG-195149 (Eno3)

Protein Structure

UniProt Annotation

Function

Appears to have a function in striated muscle development and regeneration.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11229603}. Note=Localized to the Z line. Some colocalization with CKM at M- band (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. In striated muscle, the fiber-type order of ENO3 expression is IIB > IIX > IIA > I. {ECO:0000269PubMed:11229603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006096	glycolytic process
GO:0007568	aging
GO:0042493	response to drug
GO:0043403	skeletal muscle tissue regeneration

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95395

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR022662 Methylaspartate ammonia-lyase, C-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952
PF07476

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt