Version 5.4
Mus musculus Gene: Eno3
Summary
InnateDB Gene IDBG-195149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eno3
Gene Name enolase 3, beta muscle
Synonyms Eno-3; MSE
Species Mus musculus
Ensembl Gene ENSMUSG00000060600
Encoded Proteins
IDBP-195151
enolase 3, beta muscle
IDBP-264304
enolase 3, beta muscle
IDBP-539099
enolase 3, beta muscle
IDBP-542111
enolase 3, beta muscle
IDBP-534131
enolase 3, beta muscle
IDBP-624138
enolase 3, beta muscle
IDBP-716870
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70657202-70662513
Strand Forward strand
Band B3
Transcripts
ENSMUST00000072841 ENSMUSP00000072620
ENSMUST00000108548 ENSMUSP00000104188
ENSMUST00000157027 ENSMUSP00000115726
ENSMUST00000126241 ENSMUSP00000123688
ENSMUST00000134087 ENSMUSP00000121640
ENSMUST00000170716 ENSMUSP00000128714
ENSMUST00000179055 ENSMUSP00000137559
ENSMUST00000179738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006096 glycolytic process
GO:0007568 aging
GO:0021762 substantia nigra development
GO:0042493 response to drug
GO:0043403 skeletal muscle tissue regeneration
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108515
View Gene Order
ENSBTAG00000005534
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_232322
Glycolysis pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_263230
Gluconeogenesis pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_227222
Gluconeogenesis pathway
REACT_211129
Glycogen storage diseases pathway
REACT_224672
Glucose metabolism pathway
REACT_219139
Metabolism pathway
REACT_224187
Glycolysis pathway
REACT_207087
Disease pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa03018
RNA degradation pathway
INOH
INOH website
Citrate cycle pathway
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.251322
RefSeq NM_001136062 NM_001276285 NM_007933 XM_006532161 XM_006532162 XM_006537129 XM_006537130
OMIM
CCDS CCDS24961
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca