InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPM4

Summary

InnateDB Protein

IDBP-62421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM4

Protein Name

transient receptor potential cation channel, subfamily M, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252826

InnateDB Gene

IDBG-62419 (TRPM4)

Protein Structure

UniProt Annotation

Function

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. {ECO:0000269PubMed:12015988, ECO:0000269PubMed:12799367, ECO:0000269PubMed:15121803, ECO:0000269PubMed:15472118, ECO:0000269PubMed:15550671, ECO:0000269PubMed:16806463, ECO:0000269PubMed:20625999, ECO:0000269PubMed:20656926}.

Subcellular Localization

Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.Isoform 2: Endoplasmic reticulum. Golgi apparatus.

Disease Associations

Progressive familial heart block 1B (PFHB1B) [MIM:604559]: A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His- Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death. {ECO:0000269PubMed:19726882, ECO:0000269PubMed:20562447, ECO:0000269PubMed:21887725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. {ECO:0000269PubMed:11535825, ECO:0000269PubMed:12015988, ECO:0000269PubMed:12799367, ECO:0000269PubMed:15472118, ECO:0000269PubMed:16777713, ECO:0000269PubMed:19726882, ECO:0000269PubMed:20656926}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0002724	regulation of T cell cytokine production
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0008284	positive regulation of cell proliferation
GO:0016925	protein sumoylation
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0090263	positive regulation of canonical Wnt signaling pathway