InnateDB Protein
|
IDBP-624224.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Suds3
|
Protein Name
|
suppressor of defective silencing 3 homolog (S. cerevisiae)
|
Synonyms
|
2400003N08Rik; 2410008L21Rik; AU067672; mSds3;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000130535
|
InnateDB Gene
|
IDBG-194701 (Suds3)
|
Protein Structure
|
|
Function |
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in all newborn tissues tested, including brain, kidney and liver. {ECO:0000269PubMed:11909966}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
12
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1919204
|
InterPro |
IPR013907
Sds3-like
|
PFAM |
PF08598
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BR65
|
PhosphoSite |
PhosphoSite-Q8BR65
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
71954
|
UniGene |
Mm.34456
|
RefSeq |
NP_001116138
|
MGI ID |
|
MGI Symbol |
Suds3
|
OMIM |
|
CCDS |
CCDS51631
|
HPRD |
|
IMGT |
|
EMBL |
AF469109
AK043652
AK045475
AK138947
AK150633
BC055764
BC062176
|
GenPept |
AAH55764
AAH62176
AAM22676
BAC31608
BAC32387
BAE23831
BAE29722
|
|
|