InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc16a3

Summary

InnateDB Protein

IDBP-624551.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc16a3

Protein Name

solute carrier family 16 (monocarboxylic acid transporters), member 3

Synonyms

Mct3; Mct4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125846

InnateDB Gene

IDBG-214918 (Slc16a3)

Protein Structure

UniProt Annotation

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity

Biological Process

GO:0015711	organic anion transport
GO:0015718	monocarboxylic acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:1933438

InterPro

IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57787

PhosphoSite