InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfx4

Summary

InnateDB Protein

IDBP-624701.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfx4

Protein Name

regulatory factor X, 4 (influences HLA class II expression)

Synonyms

4933412G19Rik; NYD-sp10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128690

InnateDB Gene

IDBG-180793 (Rfx4)

Protein Structure

UniProt Annotation

Function

Plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. {ECO:0000269PubMed:12925582, ECO:0000269PubMed:16893423}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00858, ECO:0000269PubMed:14701801}.

Disease Associations

Tissue Specificity

Isoform 1 is brain-specific. Isoform 2 is testis-specific. Isoform 1 is highly expressed in the suprachiasmatic nucleus (at protein level), the central pacemaker site of the circadian clock. {ECO:0000269PubMed:12925582, ECO:0000269PubMed:14701801}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0021516	dorsal spinal cord development
GO:0021537	telencephalon development
GO:0021696	cerebellar cortex morphogenesis
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0042384	cilium assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070613	regulation of protein processing