InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spdef

Summary

InnateDB Protein

IDBP-624844.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spdef

Protein Name

SAM pointed domain containing ets transcription factor

Synonyms

PDEF; Pse;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127056

InnateDB Gene

IDBG-157107 (Spdef)

Protein Structure

UniProt Annotation

Function

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the accessory glands of sex organs including the prostate, seminal vesicle, coagulating gland in males, the oviduct in females, and in intestines. Expression is epithelial-specific. {ECO:0000269PubMed:10675039}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010454	negative regulation of cell fate commitment
GO:0010455	positive regulation of cell fate commitment
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060480	lung goblet cell differentiation
GO:0060576	intestinal epithelial cell development