Version 5.4
Mus musculus Gene: Spdef
Summary
InnateDB Gene IDBG-157107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spdef
Gene Name SAM pointed domain containing ets transcription factor
Synonyms PDEF; Pse
Species Mus musculus
Ensembl Gene ENSMUSG00000024215
Encoded Proteins
IDBP-157109
SAM pointed domain containing ets transcription factor
IDBP-250870
SAM pointed domain containing ets transcription factor
IDBP-539643
SAM pointed domain containing ets transcription factor
IDBP-624844
SAM pointed domain containing ets transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124664:
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27714352-27728951
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000025054 ENSMUSP00000025054
ENSMUST00000114870 ENSMUSP00000110520
ENSMUST00000127622
ENSMUST00000138970 ENSMUSP00000117743
ENSMUST00000167489 ENSMUSP00000127056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0010454 negative regulation of cell fate commitment
GO:0010455 positive regulation of cell fate commitment
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060480 lung goblet cell differentiation
GO:0060576 intestinal epithelial cell development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124664
View Gene Order
ENSBTAG00000021993
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q9WTP3
TrEMBL B2KF87
UniProt Splice Variant
Entrez Gene 30051
UniGene
RefSeq NM_013891 XM_006524379 XM_006524381 XM_006536770 XM_006536772
OMIM
CCDS CCDS28568
HPRD
IMGT
MGI ID MGI:1353422
MGI Symbol Spdef
EMBL AB019436 AC131800 AK078863 BC012648
GenPept AAH12648 BAA77329 BAC37426
RNA Seq Atlas 30051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca