InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf5

Summary

InnateDB Protein

IDBP-624914.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf5

Protein Name

interferon regulatory factor 5

Synonyms

AW491843; mirf5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127021

InnateDB Gene

IDBG-132026 (Irf5)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18824541}. Nucleus {ECO:0000269PubMed:18824541}. Note=Shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	9 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus