Mus musculus Protein: Usp20 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-625096.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Usp20 | ||||||||||||||
Protein Name | ubiquitin specific peptidase 20 | ||||||||||||||
Synonyms | 1700055M05Rik; AI467231; Vdu2; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000127388 | ||||||||||||||
InnateDB Gene | IDBG-157301 (Usp20) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1921520 | ||||||||||||||
InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase IPR001607 Zinc finger, UBP-type IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain |
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PFAM |
PF00443
PF02148 PF06337 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00290
SM00695 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q8C6M1 | ||||||||||||||
PhosphoSite | PhosphoSite-Q8C6M1 | ||||||||||||||
TrEMBL | Q9CVR9 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 74270 | ||||||||||||||
UniGene | Mm.346654 | ||||||||||||||
RefSeq | XP_006498455 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Usp20 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS15893 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF449715 AK006800 AK054279 AK163663 AK173083 AL844546 BC019735 BC079674 CH466542 | ||||||||||||||
GenPept | AAH19735 AAH79674 AAN15803 BAB24746 BAC35715 BAD32361 BAE37447 CAM18433 EDL08500 | ||||||||||||||