Version 5.4
Mus musculus Protein: Nrf1
Summary
InnateDB Protein IDBP-625233.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrf1
Protein Name nuclear respiratory factor 1
Synonyms C87038; D6Ertd415e;
Species Mus musculus
Ensembl Protein ENSMUSP00000130108
InnateDB Gene IDBG-132563 (Nrf1)
Protein Structure
UniProt Annotation
Function Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Widely expressed in embryonic, fetal, and adult tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007005 mitochondrion organization
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:1332235
InterPro IPR019525 Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
IPR019526 Nuclear respiratory factor-1, activation binding domain
PFAM PF10491
PF10492
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WU00
PhosphoSite PhosphoSite-Q9WU00
TrEMBL Q8BSP8
UniProt Splice Variant
Entrez Gene 18181
UniGene Mm.412333
RefSeq XP_006505070
MGI ID
MGI Symbol Nrf1
OMIM
CCDS CCDS19968
HPRD
IMGT
EMBL AF098077 AK014494 AK029034 AK031103 CH466533
GenPept AAD21938 BAB29394 BAC26256 BAC27254 EDL13755 EDL13757

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca